DelveInsight’s, “T-cell Malignancies Pipeline Insight 2024” report provides comprehensive insights about 80+ companies and 82+ pipeline drugs in T-cell Malignancies pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
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Key Takeaways from the T-Cell Malignancies Pipeline Report
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T-cell Malignancies Emerging Drugs Profile
Masitinib is a new orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases. Based on its unique mechanism of action, masitinib can be developed in a large number of conditions in oncology, in inflammatory diseases, and in certain diseases of the central nervous system. In oncology due to its immunotherapy effect, masitinib can have an effect on survival, alone or in combination with chemotherapy. The drug is currently being evaluated under Phase III clinical trial for the treatment of patients with T-cell malignancies.
Soquelitinib (formerly known as CPI-818) is an investigational small molecule drug given orally designed to selectively inhibit ITK (interleukin-2-inducible T cell kinase), an enzyme that is expressed predominantly in T cells and plays a role in T cell and natural killer (NK) cell immune function. The drug is currently being evaluated under Phase II clinical trial for the treatment of patients with T-cell malignancies.
Golcadomide is a novel, oral CELMoD agent representing one of several compelling assets generated from our differentiated targeted protein degradation research platform. The drug is currently being evaluated under Phase I/II clinical trial for the treatment of patients with T-cell malignancies.
KT-333 is a potent, highly selective degrader of STAT3 in development for the treatment of multiple STAT3-dependent pathologies, including hematological malignancies and solid tumors. STAT3 is an undrugged transcription factor activated through a variety of different cytokine and growth factor receptors via Janus kinases (JAKs), as well as through oncogenic fusion proteins and mutations in STAT3 itself. In certain malignant cells, STAT3 activation is set into overdrive, leading to a dampened immune response, tumor progression, and metastasis. The drug is currently being evaluated under Phase I clinical trial for the treatment of patients with T-cell malignancies.
NeoX developed NXD02, to improve the therapeutic window by mitigating platelet toxicity through neoX’s AI-empowered degrader design platform, neoDegrader. The drug is currently in the Preclinical stage of development for the treatment of patients with T-cell Malignancies.
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T-cell Malignancies pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration.
T-cell Malignancies Products have been categorized under various Molecule types such as
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Scope of the T-cell Malignancies Pipeline Report
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