The Treatment Resistant Depression treatment market offers tremendous opportunities to pharmaceutical players since there are only a few approved non-nicotinic therapies available commercially. The Treatment Resistant Depression market research report covers the Treatment Resistant Depression market trends covering key pharmaceutical companies in the market, upcoming as well as Treatment Resistant Depression marketed therapies, unmet needs, prevailing constraints and the factors driving the Treatment Resistant Depression market size growth.
Key takeaways from the Treatment Resistant Depression Market Research Report
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Treatment Resistant Depression Overview
Treatment-resistant Depression (TRD) typically refers to inadequate response to at least two antidepressant medications used for a sufficient length of time at an adequate dose with an adequate affirmation of treatment adherence. TRD is a relatively common occurrence in clinical practice, with up to 50–60% of the patients not achieving adequate response following antidepressant treatment.
Treatment Resistant Depression Epidemiology Segmentation in the 7MM
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Treatment-resistant Depression Emerging Drugs
AXS-05: Axsome Therapeutics
AXS-05 is a novel, oral, investigational NMDA receptor antagonist with multimodal activity. It consists of a proprietary formulation and dose of dextromethorphan (DM) and bupropion and is being developed to treat central nervous system (CNS) conditions. The FDA granted Priority Review to Axsome Therapeutics’ AXS-05 (dextromethorphan-bupropion). The accelerated review framework shortens the review duration from a standard 10-month period to 6 months after its New Drug Application (NDA) acceptance.
VRAYLAR (Cariprazine): AbbVie
Cariprazine is an oral, once-daily atypical antipsychotic. It is a potent central dopamine D3 and D2 receptor partial agonist, which preferentially binds to the D3 receptor. It also has partial agonist activity at serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Pharmacodynamic studies with cariprazine have shown that it acts as a partial agonist with a high binding affinity at dopamine D3, dopamine D2, and serotonin 5-HT1A receptors. Cariprazine demonstrated up to eightfold greater in vitro affinity for dopamine D3 vs. D2 receptors. Cariprazine also acts as an antagonist at serotonin 5-HT2B and 5-HT2A receptors with high and moderate binding affinity, respectively, as well as it binds to the histamine H1 receptors. It shows a lower binding affinity to the serotonin 5-HT2C and α1A-adrenergic receptors and has no appreciable affinity for cholinergic muscarinic receptors.
Treatment-resistant Depression Market Outlook
Various new therapies are in development, focusing on alleviating the limitations of the currently approved drugs. Some of the most prominent ones include AXS-05 (Axsome Therapeutics), Cariprazine (AbbVie), Esketamine DPI (Celon Pharma), AV-101 (VistaGen Therapeutics), REL-1017 (Relmada Therapeutics, Inc./Syneos Health ), MIJ821 (Novartis Pharmaceuticals ), among others. The market is poised to take off with novel candidates and regulators facilitating drug development with various designations, including Breakthrough Therapy, Orphan Drug Designation, etc. In addition, market analysis shows immense Go-To-Market challenges such as manufacturing and commercialization strategies, pricing decisions, reimbursement negotiations, making the Treatment-resistant Depression (TRD) market one of the trickiest to navigate through.
Treatment-resistant Depression Key Companies and Pipeline Therapies
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Scope of the Treatment-resistant Depression Market Research Report
Table of Content
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